Novel ACE inhibitory tripeptides from ovotransferrin using bioinformatics and peptidomics approaches

Developmental control of CFTR: from bioinformatics to novel therapeutic approaches.

Celebrating the 25th anniversary of identifying the genetic cause of cystic fibrosis (CF), tremendous progress has been made in the understanding and the treatment of this complex, but still fatal disease [1]. Despite advances, several key questions about the pathomechanisms of CF remain poorly understood. For instance, the precise genetic and epigenetic mechanisms that regulate expression and ...

Egg White Ovotransferrin‐Derived ACE Inhibitory Peptide Ameliorates Angiotensin II‐Stimulated Insulin Resistance in Skeletal Muscle Cells

SCOPE The renin-angiotensin system (RAS) is a major contributor to the development of insulin resistance and its related complications. Egg white ovotransferrin-derived tripeptides, IRW (Ile-Arg-Trp), IQW (Ile-Gln-Trp), or LKP (Leu-Lys-Pro) are previously identified as the inhibitors of angiotensin-converting enzyme (ACE), a key enzyme in the RAS. This study aims at determining whether these pe...

Novel microRNA Cloning Using Bioinformatics

Novel Bioinformatics Approaches for Analysis of High-Throughput Biological Data

1Department of Computer Science and Engineering, Yuan Ze University, Taoyuan 320, Taiwan 2Innovation Center for Big Data and Digital Convergence, Yuan Ze University, Taoyuan 320, Taiwan 3Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan 320, Taiwan 4Institute of Tropical Plant Sciences, National Cheng Kung University, Tainan 701, Taiwan 5Graduate Institute of...

Polysaccharide with antioxidant, α-amylase inhibitory and ACE inhibitory activities from Momordica charantia.

Functional polysaccharide was isolated from Momordica charantia, with a yield of 36% (w/w). M. charantia bioactive polysaccharide (MCBP) was an acidic and branched heteropolysaccharide with a molecular weight of 92 kDa. Fourier transform infrared spectroscopic analysis indicated that MCBP was a pectin-like polysaccharide with an esterification degree of 53% and it contains numerous monosacchari...